rheumatology

A 59-year-old with recurrent gout, on multiple medications, has started allopurinol and naproxen. The uric acid level is 0.58. What is the target uric acid level?

A 45-year-old man presents to the clinic with a 2-week history of a painful, swollen left knee. He denies any trauma or fever. On examination, the knee is warm, swollen, and tender with a limited range of motion. Aspiration of the knee joint reveals cloudy fluid with a white blood cell count of 50,000/mm³ and needle-shaped crystals that are negatively birefringent under polarized light microscopy. What is the most appropriate initial treatment for this condition?

A 45-year-old woman presents to the emergency department with a 3-day history of progressive shortness of breath, dry cough, and fatigue. She has a history of systemic lupus erythematosus (SLE) and is currently on hydroxychloroquine and low-dose prednisone. She denies fever, chest pain, or recent travel. On examination, her temperature is 37.2°C, blood pressure is 110/70 mmHg, heart rate is 95 bpm, respiratory rate is 22 breaths per minute, and oxygen saturation is 89% on room air. Lung auscultation reveals bilateral basal crackles. Laboratory tests show a hemoglobin level of 10.5 g/dL, white blood cell count of 4,000/mm³, and platelets of 150,000/mm³. Arterial blood gas analysis reveals a pH of 7.45, PaCO2 of 35 mmHg, and PaO2 of 55 mmHg. A chest X-ray shows bilateral interstitial infiltrates. Which of the following is the most appropriate next step in management?

A 10-year-old boy presents to the pediatric clinic with a history of fever, a rash characterized by erythema marginatum, and migratory arthralgia. His mother reports that he had a sore throat about three weeks ago, which resolved without treatment. On examination, he has a temperature of 38.5°C, a heart rate of 110 bpm, and a faint erythematous rash on his trunk. His joints are tender but not swollen. Given the suspicion of acute rheumatic fever, which of the following is the most appropriate next step in management?

A 32-year-old woman presents to her general practitioner with a 2-week history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. On examination, she has a malar rash and mild swelling of the small joints in her hands. Laboratory tests reveal a positive antinuclear antibody (ANA) and anti-double-stranded DNA antibodies. What is the most likely diagnosis?

A 32-year-old woman presents to her GP with a 3-month history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. On examination, she has a malar rash and mild swelling of the small joints of her hands. Laboratory tests reveal a positive ANA and anti-dsDNA antibodies. What is the most likely diagnosis?

A 25-year-old man presents to the clinic with a 2-week history of a painful, swollen right knee. He denies any trauma or recent travel. He has a history of psoriasis. On examination, the right knee is warm, swollen, and tender with a reduced range of motion. There are no other joint abnormalities. What is the most likely diagnosis?

A 60-year-old woman presents to the clinic with a 2-month history of progressive shortness of breath and a dry cough. She has a history of rheumatoid arthritis and is currently on methotrexate and low-dose prednisone. On examination, she has fine inspiratory crackles at the lung bases. A high-resolution CT scan of the chest shows reticular opacities and honeycombing predominantly in the lower lobes. What is the most likely diagnosis?

A 32-year-old woman presents to her general practitioner with a 2-week history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. Laboratory tests reveal anemia, leukopenia, and positive antinuclear antibodies (ANA). What is the most likely diagnosis?

A 60-year-old woman presents to her GP with a 3-month history of increasing fatigue and joint pain, particularly in her hands and knees. She also reports morning stiffness lasting over an hour. On examination, there is swelling and tenderness in the metacarpophalangeal and proximal interphalangeal joints. Blood tests reveal a positive rheumatoid factor and elevated C-reactive protein. What is the most appropriate initial treatment for her condition?

A 32-year-old woman presents to her general practitioner with a 3-month history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. On examination, she has a malar rash, mild synovitis in her hands, and no signs of organomegaly. Laboratory tests reveal anemia, leukopenia, and positive antinuclear antibodies (ANA) with a high titer. Which of the following is the most appropriate initial management for this patient?

A 32-year-old woman presents to the clinic with a 3-week history of joint pain, morning stiffness lasting over an hour, and swelling in her hands and wrists. She has no significant past medical history and is not on any medications. On examination, there is synovitis in the metacarpophalangeal and proximal interphalangeal joints bilaterally. What is the most likely diagnosis?

A 28-year-old woman presents to her general practitioner with a 2-week history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. On examination, she has a malar rash and mild swelling in her hands. Laboratory tests reveal a positive antinuclear antibody (ANA) test and elevated anti-double-stranded DNA antibodies. What is the most likely diagnosis?